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James J. Fabrizio
James Fabrizio 2013 Chair, Health Professions Advisory Committee
Associate Professor of Biology

Post-doctoral training, University of Pennsylvania
Ph.D., St. John's University 
B.S., Manhattan College
Areas of Interest
  • Spermatogenesis
  • Drosophila genetics
  • Microscopy
  • Molecular Biology

  • BIOL 111 General Biology
  • BIOL 310, 410 Research in Biology
  • BIOL 321 Molecular Biology
  • BIOL 302 Developmental Biology
  • BIOL 217 Genetics
  • BIOL 331 Cell Biology  
Research Interests
Our lab seeks to uncover genes involved in the late-stage maturation of spermatozoa in Drosophila.  Specifically, since sperm in all animal species occurs within a common cytoplasm, all animals have to resolve individual sperm from this cytoplasm in a process known as spermatid individualization. Indeed, a failure to individualize sperm is the predominant cause of male infertility in humans. Given the genetic similarity (65–70 percent) between Drosophila and humans, we hope our work will shed some light on the molecular mechanisms behind human male fertility.

External Research Support
Dr. Fabrizio received a National Institutes of Health grant for $200,000 as principal investigator. He will be incorporating methods and knowledge of genetics, molecular biology, cell biology, and genomics to study sperm development in the fruit fly, or Drosophila melanogaster.

Recent Publications
Fabrizio, J.J., Aqeel, N., Cote, J., Estevez, J., Jongoy, M., Mangal, V., Tema, W., Rivera, A., Wnukowski, J. and Bencosme, Y. 2012. mulet (mlt) encodes a tubulin-binding cofactor E-like homolog required for spermatid individualization in Drosophila melanogaster. Fly 6:4, 261-272;

Fabrizio, J.J., Hickey, C.A., Stabrawa, C., Meytes, V., Hutter, J.A., Talbert, C., and Regis, N. 2008. Imp (IGF-II mRNA binding protein) is expressed during spermatogenesis in Drosophila melanogaster. Fly 2:1, 47-52.

Fabrizio, J. J., M. Boyle, and S. DiNardo. 2003. A somatic role for eyes absent (eya) and sine oculis (so) in Drosophila spermatocyte development. Developmental Biology 258: 117–28.

Fabrizio, J. J., G. Hime, S.K. Lemmon, and C. Bazinet. 1998. Genetic dissection of sperm individualization in Drosophila melanogaster.  Development 125: 1833–43.