|
James J. Fabrizio
.jpg)
|
Chair, Health Professions Advisory Committee Associate Professor of Biology Post-doctoral training, University of Pennsylvania Ph.D., St. John's University B.S., Manhattan College |
|
|
Contact Information: Lab Phone: (718) 405-3393 Office Phone: (718) 405-3383 james.fabrizio@mountsaintvincent.edu Science Building, Rooms 103 and 303 (Lab) |
Courses Taught:
|
|
Research Interests: Our lab seeks to uncover genes involved in the maturation of spermatozoa in Drosophila. To this end, we are screening a large collection of GFP-tagged protein traps and enhancer traps for gene expression in the late stages of spermatogenesis. When a gene is found, it is isolated and sequenced using molecular biology techniques, and mutants are obtained in order to ascertain the function of the gene. This work will result in the genetic dissection of sperm morphogenesis. Moreover, given the genetic similarity (65–70 percent) between Drosophila and humans, this work also has implications for human male fertility. External Research Support: Dr. Fabrizio received a National Institutes of Health grant for $200,000 as principal investigator. He will be incorporating methods and knowledge of genetics, molecular biology, cell biology, and genomics to study sperm development in the fruit fly, or Drosophila melanogaster. Recent Publications: Fabrizio, J.J., Hickey, C.A., Stabrawa, C., Meytes, V., Hutter, J.A., Talbert, C., and Regis, N. 2008. Imp (IGF-II mRNA binding protein) is expressed during spermatogenesis in Drosophila melanogaster. Fly 2:1, 47-52.
Fabrizio, J. J., M. Boyle, and S. DiNardo. 2003. A somatic role for eyes absent (eya) and sine oculis (so) in Drosophila spermatocyte development. Developmental Biology 258: 117–28. |