Assistant Professor of Chemistry
Ph.D., Stony Brook University
B.S., St. John's University
Areas of Interest
Metalloproteins, by definition, are proteins that contain transition metals that are involved in a wide range of biological processes. Currently, the energy infrastructure is dominated by fossil fuel production and combustion. Hydrogen is often suggested as alternative fuel, sometimes called the “fuel of the future.” Scientists have turned to biological systems that utilized hydrogen in order to develop new catalysts that do not require platinum group metals. These biological systems are called hydrogenases, where the active site was found to contain an iron/nickel dinuclear core. Our laboratory is particularly interested in synthesizing and characterizing transition metals complexes that model the biological active site.
Since Rosenberg reported cisplatin in 1965, PtII(NH3)2Cl2, to be the first generation antitumor agent, more platinum complexes and platinum series metal complexes have been examined further for their antitumor activity and selectivity. Cisplatin is very effective towards cancers like testicular and ovarian cancer, however it produce severe side effects to patients. Our laboratory is interested in synthesizing and characterizing new platinum group transition metal complexes that can be used as potential candidates for antitumor agents.
St. John’s University
Stony Brook University
Ishwar R. Sadarangani, Souful Bhatia, Daniel Amarante, Istvan Lengyel, Ralph A. Stephani; Synthesis, resolution and anticonvulsant activity of chiral N-1’-ethyl',N-3’'-(1-phenylethyl-(R,S)-2’H,3H,5’H-spiro-(2-benzofuran-1,4’'-imidazolidine)-2’,3,5’'-trione diastereomers. Bioorganic & Medicinal Chemistry Letters; Bioorganic & Medicinal Chemistry Letters 2012, 22, 2507-2509.
Daniel Amarante, Cheryl Cherian, Stephanie Ovalles, Elise G. Megehee; Synthesis and Characterization of Mixed Terpyridine Rhodium(III) Complexes; manuscript to be submitted.
Daniel Amarante, Cheryl Cherian, Elise G. Megehee; Improved Synthesis of Mixed Diimine Ligand Rhodium(III) Complexes using a Versatile Triflate Precursor; manuscript to be submitted.
Daniel Amarante, Cheryl Cherian, Anthony Catapano, Rebekah Adams, Man Hoi Wang, Elise G. Megehee; Synthesis and Electronic Characterization of Bipyridine Dithiolate Rhodium(III) Complexes. Inorg. Chem. 2005, 44, 8804-8809.
Daniel Amarante, Cheryl Cherian, Christopher Emmel, Noreen Hui-Yun Chen, Saraswati Dayal, Mary Koshy, Elise G. Megehee; Improved synthetic routes to rhodium bipyridine complexes: Comparison of microwave vs. conventional synthesis. Inorg. Chim. Acta 2005, 358, 2231-2238.